Cancer Breakthroughs: ASCO spotlighted new oncology data, including pancreatic cancer drugs that at least doubled survival in trials, with Revolution Medicines and Merck drawing top analyst buzz. Trump & Intelligence: Trump named FHFA director Bill Pulte as acting national intelligence director, drawing sharp pushback over his lack of national security credentials. Trade & Canada Tensions: U.S. Ambassador Pete Hoekstra revived Trump’s “51st state” talk as Canada’s PM Mark Carney shrugged it off ahead of trade talks; the U.S. also moves toward forced-labor import levies and broader tariff plans. Markets & Inflation Watch: Gold keeps climbing past U.S. Treasuries as the biggest reserve asset while oil jumps on U.S.-Iran strikes, stalling a record U.S. stock rally. Jobs: Job openings hit a two-year high with 7.6 million openings in April, even as hiring cooled slightly. Middle East: Iran-U.S. talks continue via mediators despite big gaps, while Hezbollah rockets and Israeli strikes test a U.S.-mediated Lebanon ceasefire. Public Health: Colorado logged its 23rd measles case; officials are investigating possible local exposure. Education Staffing: Louisiana and other states face major teacher shortages, with thousands of unfilled roles and many teachers not fully certified. Energy & Infrastructure: The Army Corps awarded an $85M design/engineering contract for Great Lakes invasive carp prevention at Brandon Road; Urenco plans major uranium enrichment expansion in New Mexico. Agriculture Alert: USDA says New World screwworm was detected in Mexico near the border, keeping Texas on watch. California Politics: California’s governor primary remained too close to call early Wednesday as votes were still being counted.